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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CIITA All Species: 5.45
Human Site: Y428 Identified Species: 15
UniProt: P33076 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33076 NP_000237.2 1130 123443 Y428 K A G Q G K S Y W A G A V S R
Chimpanzee Pan troglodytes Q53B87 1040 115280 S402 C S P T D P T S V Q T L L F N
Rhesus Macaque Macaca mulatta XP_001103518 1130 123636 Y428 K A G Q G K S Y W A G A V S R
Dog Lupus familis XP_547128 1104 119761 C406 K A G Q G K S C W A R E V S R
Cat Felis silvestris
Mouse Mus musculus P79621 1155 127510 H453 K A G Q G K S H W A R T V S H
Rat Rattus norvegicus NP_445981 1153 127283 H454 K A G Q G K S H W A R T V S H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516927 965 106480 Q332 I Y D L A E R Q K A H V G R R
Chicken Gallus gallus XP_425250 824 93504 K191 K Q I S L P E K W Y S L K D L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001343072 1044 115802 N395 S P H C E D S N A A F K H I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.7 94.3 77.1 N.A. 61.3 61.3 N.A. 37.7 34.2 N.A. 32.1 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 35.2 96.6 84.3 N.A. 72.2 71.4 N.A. 52.1 47.4 N.A. 48.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 100 80 N.A. 73.3 73.3 N.A. 13.3 13.3 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 100 80 N.A. 80 80 N.A. 20 13.3 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 56 0 0 12 0 0 0 12 78 0 23 0 0 0 % A
% Cys: 12 0 0 12 0 0 0 12 0 0 0 0 0 0 0 % C
% Asp: 0 0 12 0 12 12 0 0 0 0 0 0 0 12 0 % D
% Glu: 0 0 0 0 12 12 12 0 0 0 0 12 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 12 0 0 12 0 % F
% Gly: 0 0 56 0 56 0 0 0 0 0 23 0 12 0 0 % G
% His: 0 0 12 0 0 0 0 23 0 0 12 0 12 0 23 % H
% Ile: 12 0 12 0 0 0 0 0 0 0 0 0 0 12 0 % I
% Lys: 67 0 0 0 0 56 0 12 12 0 0 12 12 0 0 % K
% Leu: 0 0 0 12 12 0 0 0 0 0 0 23 12 0 23 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 12 % N
% Pro: 0 12 12 0 0 23 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 12 0 56 0 0 0 12 0 12 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 12 0 0 0 34 0 0 12 45 % R
% Ser: 12 12 0 12 0 0 67 12 0 0 12 0 0 56 0 % S
% Thr: 0 0 0 12 0 0 12 0 0 0 12 23 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 12 0 0 12 56 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 % W
% Tyr: 0 12 0 0 0 0 0 23 0 12 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _